Vaccine induction of antibodies and tissue-resident CD8(+) T cells enhances protection against mucosal SHIV-infection in young macaques

Antibodies and cytotoxic T cells represent 2 arms of host defense against pathogens. We hypothesized that vaccines that induce both high-magnitude CD8(+) T cell responses and antibody responses might confer enhanced protection against HIV. To test this hypothesis, we immunized 3 groups of nonhuman p...

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Udgivet i:JCI Insight
Main Authors: Petitdemange, Caroline, Kasturi, Sudhir Pai, Kozlowski, Pamela A., Nabi, Rafiq, Quarnstrom, Clare F., Reddy, Pradeep Babu Jagadeesh, Derdeyn, Cynthia A., Spicer, Lori M., Patel, Parin, Legere, Traci, Kovalenkov, Yevgeniy O., Labranche, Celia C., Villinger, François, Tomai, Mark, Vasilakos, John, Haynes, Barton, Kang, C. Yong, Gibbs, James S., Yewdell, Jonathan W., Barouch, Dan, Wrammert, Jens, Montefiori, David, Hunter, Eric, Amara, Rama R., Masopust, David, Pulendran, Bali
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478416/
https://ncbi.nlm.nih.gov/pubmed/30830870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126047
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