HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium limits antigen uptake. Here we utilize a modified needle-free injector to deliver immunizations to the sublingual and buccal (SL/B) tissue of rhesus macaques. Needle-free SL/B vaccination with modifi...

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Vydáno v:Nat Commun
Hlavní autoři: Jones, Andrew T., Shen, Xiaoying, Walter, Korey L., LaBranche, Celia C., Wyatt, Linda S., Tomaras, Georgia D., Montefiori, David C., Moss, Bernard, Barouch, Dan H., Clements, John D., Kozlowski, Pamela A., Varadarajan, Raghavan, Amara, Rama Rao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379385/
https://ncbi.nlm.nih.gov/pubmed/30778066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08739-4
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