CD40L-Adjuvanted DNA/Modified Vaccinia Virus Ankara Simian Immunodeficiency Virus (SIV) Vaccine Enhances Protection against Neutralization-Resistant Mucosal SIV Infection

Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to...

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Veröffentlicht in:J Virol
Hauptverfasser: Kwa, Suefen, Sadagopal, Shanmugalakshmi, Shen, Xiaoying, Hong, Jung Joo, Gangadhara, Sailaja, Basu, Rahul, Victor, Blandine, Iyer, Smita S., LaBranche, Celia C., Montefiori, David C., Tomaras, Georgia D., Villinger, Francois, Moss, Bernard, Kozlowski, Pamela A., Amara, Rama Rao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442387/
https://ncbi.nlm.nih.gov/pubmed/25653428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03527-14
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