LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro

The phosphatase Wip1 attenuates the DNA damage response (DDR) by removing phosphorylation marks from a number of DDR proteins (p53, MDM2, Chk1/2, p38). Wip1 also dephosphorylates and inactivates RelA. Notably, LZAP, a putative tumor suppressor, has been linked to dephosphorylation of several of thes...

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Publicado en:Cell Cycle
Main Authors: Wamsley, J. Jacob, Issaeva, Natalia, An, Hanbing, Lu, Xinyuan, Donehower, Lawrence A., Yarbrough, Wendell G.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283812/
https://ncbi.nlm.nih.gov/pubmed/28027003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1261767
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