WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma

The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively regulates multiple proteins involved in DNA damage response including p53, CHK2, Histone H2AX, and ATM, and it has been shown to be overexpressed or amplified in human cancers including breast and ovaria...

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Vydáno v:PLoS One
Hlavní autoři: Richter, Mark, Dayaram, Tajhal, Gilmartin, Aidan G., Ganji, Gopinath, Pemmasani, Sandhya Kiran, Van Der Key, Harjeet, Shohet, Jason M., Donehower, Lawrence A., Kumar, Rakesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319922/
https://ncbi.nlm.nih.gov/pubmed/25658463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115635
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