The Oncogenic Phosphatase WIP1 Negatively Regulates Nucleotide Excision Repair

Nucleotide excision repair (NER) is the only mechanism in humans to repair UV-induced DNA lesions such as pyrimidine (6–4) pyrimidone photoproducts and cyclobutane pyrimidine dimers (CPD). In response to UV damage, the ataxia telangiectasia mutated and Rad3-related (ATR) kinase phosphorylates and ac...

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Main Authors: Nguyen, Thuy-Ai, Slattery, Scott D., Moon, Sung-Hwan, Darlington, Yolanda F., Lu, Xiongbin, Donehower, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893264/
https://ncbi.nlm.nih.gov/pubmed/20451471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.04.005
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