Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

In response to DNA double strand breaks, the histone variant H2AX at the break site is phosphorylated at serine 139 by DNA damage sensor kinases such as ataxia telangiectasia-mutated, forming γ-H2AX. This phosphorylation event is critical for sustained recruitment of other proteins to repair the bre...

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Bibliographische Detailangaben
Hauptverfasser: Moon, Sung-Hwan, Lin, Lin, Zhang, Xinna, Nguyen, Thuy-Ai, Darlington, Yolanda, Waldman, Alan S., Lu, Xiongbin, Donehower, Lawrence A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857113/
https://ncbi.nlm.nih.gov/pubmed/20118229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071696
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