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Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair
In response to DNA double strand breaks, the histone variant H2AX at the break site is phosphorylated at serine 139 by DNA damage sensor kinases such as ataxia telangiectasia-mutated, forming γ-H2AX. This phosphorylation event is critical for sustained recruitment of other proteins to repair the bre...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857113/ https://ncbi.nlm.nih.gov/pubmed/20118229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071696 |
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