Absence of Wip1 partially rescues Atm deficiency phenotypes in mice

Wildtype p53-Induced Phosphatase 1 (WIP1) is a serine/threonine phosphatase that dephosphorylates proteins in the ataxia telangiectasia mutated (ATM)-initiated DNA damage response pathway. WIP1 may play a homeostatic role in ATM signaling by returning the cell to a normal pre-stress state following...

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Main Authors: Darlington, Yolanda, Nguyen, Thuy-Ai, Moon, Sung-Hwan, Herron, Alan, Rao, Pulivarthi, Zhu, Chengming, Lu, Xiongbin, Donehower, Lawrence A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197977/
https://ncbi.nlm.nih.gov/pubmed/21765465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.303
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