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WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma

The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively regulates multiple proteins involved in DNA damage response including p53, CHK2, Histone H2AX, and ATM, and it has been shown to be overexpressed or amplified in human cancers including breast and ovaria...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Richter, Mark, Dayaram, Tajhal, Gilmartin, Aidan G., Ganji, Gopinath, Pemmasani, Sandhya Kiran, Van Der Key, Harjeet, Shohet, Jason M., Donehower, Lawrence A., Kumar, Rakesh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319922/
https://ncbi.nlm.nih.gov/pubmed/25658463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115635
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