A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

The tumour suppressor ARF (alternative reading frame) is encoded by the INK4a (inhibitor of cyclin-dependent kinase 4)/ARF locus, which is frequently altered in human tumours. ARF binds MDM2 (murine double minute 2) and releases p53 from inhibition by MDM2, resulting in stabilization, accumulation a...

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Bibliographic Details
Main Authors: Wang, Jialiang, He, Xiaping, Luo, Ying, Yarbrough, Wendell G.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360699/
https://ncbi.nlm.nih.gov/pubmed/16173922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050960
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