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PKM2, cancer metabolism, and the road ahead

A major metabolic aberration associated with cancer is a change in glucose metabolism. Isoform selection of the glycolytic enzyme pyruvate kinase has been implicated in the metabolic phenotype of cancer cells, and specific pyruvate kinase isoforms have been suggested to support divergent energetic a...

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Detalles Bibliográficos
Publicado en:EMBO Rep
Main Authors: Dayton, Talya L, Jacks, Tyler, Vander Heiden, Matthew G
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283597/
https://ncbi.nlm.nih.gov/pubmed/27856534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643300
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