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PKM2 is not required for colon cancer initiated by APC loss
BACKGROUND: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic...
Tallennettuna:
| Julkaisussa: | Cancer Metab |
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| Päätekijät: | , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
BioMed Central
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5707917/ https://ncbi.nlm.nih.gov/pubmed/29214019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0172-1 |
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