PKM2 is not required for colon cancer initiated by APC loss

BACKGROUND: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Metab
Main Authors: Lau, Allison N., Israelsen, William J., Roper, Jatin, Sinnamon, Mark J., Georgeon, Larissa, Dayton, Talya L., Hillis, Alissandra L., Yilmaz, Omer H., Di Vizio, Dolores, Hung, Kenneth E., Vander Heiden, Matthew G.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707917/
https://ncbi.nlm.nih.gov/pubmed/29214019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0172-1
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