PKM2 is not required for colon cancer initiated by APC loss

BACKGROUND: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cancer Metab
Autores principales: Lau, Allison N., Israelsen, William J., Roper, Jatin, Sinnamon, Mark J., Georgeon, Larissa, Dayton, Talya L., Hillis, Alissandra L., Yilmaz, Omer H., Di Vizio, Dolores, Hung, Kenneth E., Vander Heiden, Matthew G.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707917/
https://ncbi.nlm.nih.gov/pubmed/29214019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0172-1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares