PKM2 is not required for colon cancer initiated by APC loss

BACKGROUND: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic...

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Detalles Bibliográficos
Publicado en:Cancer Metab
Main Authors: Lau, Allison N., Israelsen, William J., Roper, Jatin, Sinnamon, Mark J., Georgeon, Larissa, Dayton, Talya L., Hillis, Alissandra L., Yilmaz, Omer H., Di Vizio, Dolores, Hung, Kenneth E., Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707917/
https://ncbi.nlm.nih.gov/pubmed/29214019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0172-1
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