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PKM2, cancer metabolism, and the road ahead

A major metabolic aberration associated with cancer is a change in glucose metabolism. Isoform selection of the glycolytic enzyme pyruvate kinase has been implicated in the metabolic phenotype of cancer cells, and specific pyruvate kinase isoforms have been suggested to support divergent energetic a...

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Détails bibliographiques
Publié dans:EMBO Rep
Auteurs principaux: Dayton, Talya L, Jacks, Tyler, Vander Heiden, Matthew G
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283597/
https://ncbi.nlm.nih.gov/pubmed/27856534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643300
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