STING regulates abnormal bone formation induced by deficiency of DNase II

OBJECTIVE: Cytosolic DNA sensors detect microbial DNA and promote type I interferon and pro-inflammatory cytokine production through the adaptor stimulator of interferon genes (STING) to resolve infection. Endogenous DNA also engages the STING pathway, contributing to autoimmune disease. We identifi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arthritis Rheumatol
Prif Awduron: Baum, Rebecca, Sharma, Shruti, Organ, Jason M., Jakobs, Christopher, Hornung, Veit, Burr, David B., Marshak-Rothstein, Ann, Fitzgerald, Katherine A., Gravallese, Ellen M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5274601/
https://ncbi.nlm.nih.gov/pubmed/27740718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39863
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