STING regulates abnormal bone formation induced by deficiency of DNase II

OBJECTIVE: Cytosolic DNA sensors detect microbial DNA and promote type I interferon and pro-inflammatory cytokine production through the adaptor stimulator of interferon genes (STING) to resolve infection. Endogenous DNA also engages the STING pathway, contributing to autoimmune disease. We identifi...

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Pubblicato in:Arthritis Rheumatol
Autori principali: Baum, Rebecca, Sharma, Shruti, Organ, Jason M., Jakobs, Christopher, Hornung, Veit, Burr, David B., Marshak-Rothstein, Ann, Fitzgerald, Katherine A., Gravallese, Ellen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5274601/
https://ncbi.nlm.nih.gov/pubmed/27740718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39863
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