Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR-Cas9 Gene Editing in Mice

OBJECTIVE: To identify and characterize the effect of a single nucleotide polymorphism (SNP) in the STXBP5 locus that is associated with altered thrombosis in humans. Genome wide association studies (GWAS) have identified numerous SNPs associated with human thrombotic phenotypes, but determining the...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Zhu, Qiuyu Martin, Ko, Kyung Ae, Ture, Sara, Mastrangelo, Michael A., Chen, Ming-Huei, Johnson, Andrew D., O’Donnell, Christopher J., Morrell, Craig N., Miano, Joseph M., Lowenstein, Charles J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269475/
https://ncbi.nlm.nih.gov/pubmed/28062498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308614
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