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Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR-Cas9 Gene Editing in Mice
OBJECTIVE: To identify and characterize the effect of a single nucleotide polymorphism (SNP) in the STXBP5 locus that is associated with altered thrombosis in humans. Genome wide association studies (GWAS) have identified numerous SNPs associated with human thrombotic phenotypes, but determining the...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5269475/ https://ncbi.nlm.nih.gov/pubmed/28062498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308614 |
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