Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR-Cas9 Gene Editing in Mice

OBJECTIVE: To identify and characterize the effect of a single nucleotide polymorphism (SNP) in the STXBP5 locus that is associated with altered thrombosis in humans. Genome wide association studies (GWAS) have identified numerous SNPs associated with human thrombotic phenotypes, but determining the...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Zhu, Qiuyu Martin, Ko, Kyung Ae, Ture, Sara, Mastrangelo, Michael A., Chen, Ming-Huei, Johnson, Andrew D., O’Donnell, Christopher J., Morrell, Craig N., Miano, Joseph M., Lowenstein, Charles J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269475/
https://ncbi.nlm.nih.gov/pubmed/28062498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308614
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