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Structure-Activity Relationships of the MEPicides: N-acyl and O-linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis
Despite continued research efforts, the threat of drug resistance from a variety of bacteria continues to plague clinical communities. Discovery and validation of novel biochemical targets will facilitate development of new drugs to combat these organisms. The methylerythritol phosphate (MEP) pathwa...
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Publié dans: | ACS Infect Dis |
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Auteurs principaux: | , , , , , , , , , , , |
Format: | Artigo |
Langue: | Inglês |
Publié: |
2016
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5266543/ https://ncbi.nlm.nih.gov/pubmed/27676224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00125 |
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