Structure-Activity Relationships of the MEPicides: N-acyl and O-linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis

Despite continued research efforts, the threat of drug resistance from a variety of bacteria continues to plague clinical communities. Discovery and validation of novel biochemical targets will facilitate development of new drugs to combat these organisms. The methylerythritol phosphate (MEP) pathwa...

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Détails bibliographiques
Publié dans:ACS Infect Dis
Auteurs principaux: San Jose, Géraldine, Jackson, Emily R., Haymond, Amanda, Johny, Chinchu, Edwards, Rachel L., Wang, Xu, Brothers, R. Carl, Edelstein, Emma K., Odom, Audrey R., Boshoff, Helena I., Couch, Robin D., Dowd, Cynthia S.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266543/
https://ncbi.nlm.nih.gov/pubmed/27676224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00125
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