Structure-Activity Relationships of the MEPicides: N-acyl and O-linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis

Despite continued research efforts, the threat of drug resistance from a variety of bacteria continues to plague clinical communities. Discovery and validation of novel biochemical targets will facilitate development of new drugs to combat these organisms. The methylerythritol phosphate (MEP) pathwa...

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Publicado en:ACS Infect Dis
Autores principales: San Jose, Géraldine, Jackson, Emily R., Haymond, Amanda, Johny, Chinchu, Edwards, Rachel L., Wang, Xu, Brothers, R. Carl, Edelstein, Emma K., Odom, Audrey R., Boshoff, Helena I., Couch, Robin D., Dowd, Cynthia S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266543/
https://ncbi.nlm.nih.gov/pubmed/27676224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00125
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