Structure-Activity Relationships of the MEPicides: N-acyl and O-linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis

Despite continued research efforts, the threat of drug resistance from a variety of bacteria continues to plague clinical communities. Discovery and validation of novel biochemical targets will facilitate development of new drugs to combat these organisms. The methylerythritol phosphate (MEP) pathwa...

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Bibliografiska uppgifter
I publikationen:ACS Infect Dis
Huvudupphovsmän: San Jose, Géraldine, Jackson, Emily R., Haymond, Amanda, Johny, Chinchu, Edwards, Rachel L., Wang, Xu, Brothers, R. Carl, Edelstein, Emma K., Odom, Audrey R., Boshoff, Helena I., Couch, Robin D., Dowd, Cynthia S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266543/
https://ncbi.nlm.nih.gov/pubmed/27676224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00125
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