Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.
The biological functions of the BCL2 gene were investigated in transgenic mice harboring human BCL2 cDNA under the control of an immunoglobulin heavy chain enhancer (E mu). Mice of a representative transgenic strain, E mu-bcl-2-22, had a great excess of B lymphocytes, immunoglobulin-secreting cells,...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1991
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52569/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924327/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8661 |
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