Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

The biological functions of the BCL2 gene were investigated in transgenic mice harboring human BCL2 cDNA under the control of an immunoglobulin heavy chain enhancer (E mu). Mice of a representative transgenic strain, E mu-bcl-2-22, had a great excess of B lymphocytes, immunoglobulin-secreting cells,...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Strasser, A, Whittingham, S, Vaux, D L, Bath, M L, Adams, J M, Cory, S, Harris, A W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52569/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924327/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8661
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