Circulating CXCR5(+)CXCR3(+)PD-1(lo) Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

HIV-1–specific broadly neutralizing antibodies (bnAbs) typically develop in individuals with continuous high-level viral replication and increased immune activation, conditions that cannot be reproduced during prophylactic immunization. Understanding mechanisms supporting bnAb development in the abs...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Martin-Gayo, Enrique, Cronin, Jacqueline, Hickman, Taylor, Ouyang, Zhengyu, Lindqvist, Madelene, Kolb, Kellie E., Schulze zur Wiesch, Julian, Cubas, Rafael, Porichis, Filippos, Shalek, Alex K., van Lunzen, Jan, Haddad, Elias K., Walker, Bruce D., Kaufmann, Daniel E., Lichterfeld, Mathias, Yu, Xu G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2017
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256133/
https://ncbi.nlm.nih.gov/pubmed/28138558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89574
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