Circulating CXCR5(+)CXCR3(+)PD-1(lo) Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

HIV-1–specific broadly neutralizing antibodies (bnAbs) typically develop in individuals with continuous high-level viral replication and increased immune activation, conditions that cannot be reproduced during prophylactic immunization. Understanding mechanisms supporting bnAb development in the abs...

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Vydáno v:JCI Insight
Hlavní autoři: Martin-Gayo, Enrique, Cronin, Jacqueline, Hickman, Taylor, Ouyang, Zhengyu, Lindqvist, Madelene, Kolb, Kellie E., Schulze zur Wiesch, Julian, Cubas, Rafael, Porichis, Filippos, Shalek, Alex K., van Lunzen, Jan, Haddad, Elias K., Walker, Bruce D., Kaufmann, Daniel E., Lichterfeld, Mathias, Yu, Xu G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256133/
https://ncbi.nlm.nih.gov/pubmed/28138558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89574
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