Circulating CXCR5(+)CXCR3(+)PD-1(lo) Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth

HIV-1–specific broadly neutralizing antibodies (bnAbs) typically develop in individuals with continuous high-level viral replication and increased immune activation, conditions that cannot be reproduced during prophylactic immunization. Understanding mechanisms supporting bnAb development in the abs...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Martin-Gayo, Enrique, Cronin, Jacqueline, Hickman, Taylor, Ouyang, Zhengyu, Lindqvist, Madelene, Kolb, Kellie E., Schulze zur Wiesch, Julian, Cubas, Rafael, Porichis, Filippos, Shalek, Alex K., van Lunzen, Jan, Haddad, Elias K., Walker, Bruce D., Kaufmann, Daniel E., Lichterfeld, Mathias, Yu, Xu G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256133/
https://ncbi.nlm.nih.gov/pubmed/28138558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89574
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