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B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

The genes encoding the heavy- and light-chain Fv regions of the monoclonal murine antibody B3, which recognizes a carbohydrate antigen on the surface of many human carcinomas, were cloned by PCR techniques and used to generate single-chain immunotoxins containing Pseudomonas exotoxin (PE). The light...

詳細記述

保存先:
書誌詳細
主要な著者: Brinkmann, U, Pai, L H, FitzGerald, D J, Willingham, M, Pastan, I
フォーマット: Artigo
言語:Inglês
出版事項: 1991
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC52560/
https://ncbi.nlm.nih.gov/pubmed/1924323
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