B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

The genes encoding the heavy- and light-chain Fv regions of the monoclonal murine antibody B3, which recognizes a carbohydrate antigen on the surface of many human carcinomas, were cloned by PCR techniques and used to generate single-chain immunotoxins containing Pseudomonas exotoxin (PE). The light...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Brinkmann, U, Pai, L H, FitzGerald, D J, Willingham, M, Pastan, I
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52560/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924323/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8616
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