B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

The genes encoding the heavy- and light-chain Fv regions of the monoclonal murine antibody B3, which recognizes a carbohydrate antigen on the surface of many human carcinomas, were cloned by PCR techniques and used to generate single-chain immunotoxins containing Pseudomonas exotoxin (PE). The light...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Brinkmann, U, Pai, L H, FitzGerald, D J, Willingham, M, Pastan, I
Format: Artigo
Langue:Inglês
Publié: 1991
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC52560/
https://ncbi.nlm.nih.gov/pubmed/1924323
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires