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Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.

B3(Fv)-PE38 is a recombinant single-chain immunotoxin in which the Fv region of carcinoma-specific antibody B3 is fused to a truncated form of Pseudomonas exotoxin (PE). The efficacy of monoclonal antibody B3 and B3 immunotoxins in cancer therapy and diagnosis may be limited by the human anti-mouse...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Benhar, I, Padlan, E A, Jung, S H, Lee, B, Pastan, I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45374/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991583/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12051
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