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A systematic method for identifying small-molecule modulators of protein–protein interactions

Discovering small-molecule modulators of protein–protein interactions is a challenging task because of both the generally noncontiguous, large protein surfaces that form these interfaces and the shortage of high-throughput approaches capable of identifying such rare inhibitors. We describe here a ro...

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Sonraí Bibleagrafaíochta
Main Authors: Horswill, Alexander R., Savinov, Sergey N., Benkovic, Stephen J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC524857/
https://ncbi.nlm.nih.gov/pubmed/15498867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406999101
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