Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

We demonstrate the efficacy of a genome-wide protocol in yeast that allows the identification of those gene products that functionally interact with small molecules and result in the inhibition of cellular proliferation. Here we present results from screening 10 diverse compounds in 80 genome-wide e...

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Главные авторы: Giaever, Guri, Flaherty, Patrick, Kumm, Jochen, Proctor, Michael, Nislow, Corey, Jaramillo, Daniel F., Chu, Angela M., Jordan, Michael I., Arkin, Adam P., Davis, Ronald W.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC321760/
https://ncbi.nlm.nih.gov/pubmed/14718668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307490100
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