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Modulating Protein–Protein Interactions with Small Molecules: The Importance of Binding Hotspots

The modulation of protein–protein interactions (PPIs) by small drug-like molecules is a relatively new area of research and has opened up new opportunities in drug discovery. However, the progress made in this area is limited to a handful of known cases of small molecules that target specific diseas...

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Detalhes bibliográficos
Main Authors: Thangudu, Ratna Rajesh, Bryant, Stephen H., Panchenko, Anna R., Madej, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433052/
https://ncbi.nlm.nih.gov/pubmed/22198293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.026
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