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Modulating Protein–Protein Interactions with Small Molecules: The Importance of Binding Hotspots
The modulation of protein–protein interactions (PPIs) by small drug-like molecules is a relatively new area of research and has opened up new opportunities in drug discovery. However, the progress made in this area is limited to a handful of known cases of small molecules that target specific diseas...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3433052/ https://ncbi.nlm.nih.gov/pubmed/22198293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.026 |
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