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Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain

Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Als...

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Autors principals: Chakravarty, Bornali, Gu, Ziwei, Chirala, Subrahmanyam S., Wakil, Salih J., Quiocho, Florante A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC524853/
https://ncbi.nlm.nih.gov/pubmed/15507492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406901101
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