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Human fatty acid synthase: Assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity

Our model of the native fatty acid synthase (FAS) depicts it as a dimer of two identical multifunctional proteins (M(r) ≈ 272,000) arranged in an antiparallel configuration so that the active Cys-SH of the β-ketoacyl synthase of one subunit (where the acyl group is attached) is juxtaposed within 2 Å...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Jayakumar, Arumugam, Chirala, Subrahmanyam S., Wakil, Salih J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24928/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9356448/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.23.12326
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