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Human fatty acid synthase: Role of interdomain in the formation of catalytically active synthase dimer

The human and animal fatty acid synthases are dimers of two identical multifunctional proteins (M(r) 272,000) arranged in an antiparallel configuration. This arrangement generates two active centers for fatty acid synthesis separated by interdomain (ID) regions and predicts that two appropriate halv...

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Detalhes bibliográficos
Main Authors: Chirala, Subrahmanyam S., Jayakumar, Armugam, Gu, Zi-Wei, Wakil, Salih J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30614/
https://ncbi.nlm.nih.gov/pubmed/11248039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051635998
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