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Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-γ-linolenic acid

Human fatty acid synthase (hFAS) is a homodimeric multidomain enzyme that catalyzes a series of reactions leading to the de novo biosynthesis of long-chain fatty acids, mainly palmitate. The carboxy-terminal thioesterase (TE) domain determines the length of the fatty acyl chain and its ultimate rele...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zhang, Wei, Chakravarty, Bornali, Zheng, Fei, Gu, Ziwei, Wu, Hongmei, Mao, Jianqiang, Wakil, Salih J., Quiocho, Florante A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179057/
https://ncbi.nlm.nih.gov/pubmed/21908709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112334108
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