New insights into the GINS complex explain the controversy between existing structural models

GINS is a key component of eukaryotic replicative forks and is composed of four subunits (Sld5, Psf1, Psf2, Psf3). To explain the discrepancy between structural data from crystallography and electron microscopy (EM), we show that GINS is a compact tetramer in solution as observed in crystal structur...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Carroni, Marta, De March, Matteo, Medagli, Barbara, Krastanova, Ivet, Taylor, Ian A., Amenitsch, Heinz, Araki, Hiroyuchi, Pisani, Francesca M., Patwardhan, Ardan, Onesti, Silvia
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223209/
https://ncbi.nlm.nih.gov/pubmed/28071757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40188
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