New insights into the GINS complex explain the controversy between existing structural models

GINS is a key component of eukaryotic replicative forks and is composed of four subunits (Sld5, Psf1, Psf2, Psf3). To explain the discrepancy between structural data from crystallography and electron microscopy (EM), we show that GINS is a compact tetramer in solution as observed in crystal structur...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Carroni, Marta, De March, Matteo, Medagli, Barbara, Krastanova, Ivet, Taylor, Ian A., Amenitsch, Heinz, Araki, Hiroyuchi, Pisani, Francesca M., Patwardhan, Ardan, Onesti, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223209/
https://ncbi.nlm.nih.gov/pubmed/28071757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40188
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