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Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase
Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed in a range of solid tumors, which is linked with tumor progression and poor prognosis. Importantly, Aurora-A inhibitors are being studied in a number o...
সংরক্ষণ করুন:
| প্রকাশিত: | Cell Discov |
|---|---|
| প্রধান লেখক: | , , , , , , , , , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
Nature Publishing Group
2017
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5223110/ https://ncbi.nlm.nih.gov/pubmed/28101375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.49 |
| ট্যাগগুলো: |
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