Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases

Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing additional time for decaten...

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Publicat a:J Cell Biol
Autors principals: Pandey, Nootan, Keifenheim, Daniel, Yoshida, Makoto Michael, Hassebroek, Victoria A., Soroka, Caitlin, Azuma, Yoshiaki, Clarke, Duncan J.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039214/
https://ncbi.nlm.nih.gov/pubmed/31712254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807189
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