Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases

Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing additional time for decaten...

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Pubblicato in:J Cell Biol
Autori principali: Pandey, Nootan, Keifenheim, Daniel, Yoshida, Makoto Michael, Hassebroek, Victoria A., Soroka, Caitlin, Azuma, Yoshiaki, Clarke, Duncan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039214/
https://ncbi.nlm.nih.gov/pubmed/31712254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807189
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