Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases

Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing additional time for decaten...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Pandey, Nootan, Keifenheim, Daniel, Yoshida, Makoto Michael, Hassebroek, Victoria A., Soroka, Caitlin, Azuma, Yoshiaki, Clarke, Duncan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039214/
https://ncbi.nlm.nih.gov/pubmed/31712254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807189
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