A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis

Haspin phosphorylates histone H3 at Thr-3 (H3T3ph) during mitosis [1, 2], providing a chromatin binding site for the chromosomal passenger complex (CPC) at centromeres to regulate chromosome segregation [3–5]. H3T3ph becomes increasingly focused at inner centromeres during prometaphase [1, 2], but l...

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Autori principali: Wang, Fangwei, Ulyanova, Natalia P., van der Waal, Maike S., Patnaik, Debasis, Lens, Susanne M.A., Higgins, Jonathan M.G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118923/
https://ncbi.nlm.nih.gov/pubmed/21658950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.05.016
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