Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase

Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed in a range of solid tumors, which is linked with tumor progression and poor prognosis. Importantly, Aurora-A inhibitors are being studied in a number o...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Yu, Fazhi, Jiang, Ya, Lu, Lucy, Cao, Mimi, Qiao, Yulong, Liu, Xing, Liu, Dan, Van Dyke, Terry, Wang, Fangwei, Yao, Xuebiao, Guo, Jing, Yang, Zhenye
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223110/
https://ncbi.nlm.nih.gov/pubmed/28101375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.49
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