Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation

Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), providing a docking site for the Aurora B complex at centromeres. Aurora B functions to correct improper kinetochore–microtubule attachments and alert the spindle checkpoint to the presence of misaligned chromosomes. We show that Haspin inhib...

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Detalhes bibliográficos
Main Authors: Wang, Fangwei, Ulyanova, Natalia P., Daum, John R., Patnaik, Debasis, Kateneva, Anna V., Gorbsky, Gary J., Higgins, Jonathan M.G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471242/
https://ncbi.nlm.nih.gov/pubmed/23071152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205106
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