טוען...
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation
Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), providing a docking site for the Aurora B complex at centromeres. Aurora B functions to correct improper kinetochore–microtubule attachments and alert the spindle checkpoint to the presence of misaligned chromosomes. We show that Haspin inhib...
שמור ב:
| Main Authors: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
The Rockefeller University Press
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471242/ https://ncbi.nlm.nih.gov/pubmed/23071152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205106 |
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