Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes

The allosteric regulation triggering the protein’s functional activity via conformational changes is an intrinsic function of protein under many physiological and pathological conditions, including cancer. Identification of the biological effects of specific somatic variants on allosteric proteins a...

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Bibliographic Details
Published in:Am J Hum Genet
Main Authors: Shen, Qiancheng, Cheng, Feixiong, Song, Huili, Lu, Weiqiang, Zhao, Junfei, An, Xiaoli, Liu, Mingyao, Chen, Guoqiang, Zhao, Zhongming, Zhang, Jian
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223033/
https://ncbi.nlm.nih.gov/pubmed/27939638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.09.020
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