Studying Tumorigenesis through Network Evolution and Somatic Mutational Perturbations in the Cancer Interactome

Cells govern biological functions through complex biological networks. Perturbations to networks may drive cells to new phenotypic states, for example, tumorigenesis. Identifying how genetic lesions perturb molecular networks is a fundamental challenge. This study used large-scale human interactome...

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Main Authors: Cheng, Feixiong, Jia, Peilin, Wang, Quan, Lin, Chen-Ching, Li, Wen-Hsiung, Zhao, Zhongming
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Discoveries
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104318/
https://ncbi.nlm.nih.gov/pubmed/24881052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu167
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