p53 Deficiency Rescues Neuronal Apoptosis but Not Differentiation in DNA Polymerase β-Deficient Mice

In mammalian cells, DNA polymerase β (Polβ) functions in base excision repair. We have previously shown that Polβ-deficient mice exhibit extensive neuronal cell death (apoptosis) in the developing nervous system and that the mice die immediately after birth. Here, we studied potential roles in the p...

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Dades bibliogràfiques
Publicat a:Mol Cell Biol
Autors principals: Sugo, Noriyuki, Niimi, Naoko, Aratani, Yasuaki, Takiguchi-Hayashi, Keiko, Koyama, Hideki
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2004
Matèries:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522222/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15485914/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.21.9470-9477.2004
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