Disruption of the COP9 Signalosome Csn2 Subunit in Mice Causes Deficient Cell Proliferation, Accumulation of p53 and Cyclin E, and Early Embryonic Death

Csn2 (Trip15/Cops2/Alien) encodes the second subunit of the COP9 signalosome (CSN), an eight-subunit heteromeric complex homologous to the lid subcomplex of the 26S proteasome. CSN is a regulator of SCF (Skp1-cullin-F-box protein)ubiquitin ligases, mostly through the enzymatic activity that deconjug...

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Autori principali: Lykke-Andersen, Karin, Schaefer, Laura, Menon, Suchithra, Deng, Xing-Wang, Miller, Jeffrey Boone, Wei, Ning
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC193936/
https://ncbi.nlm.nih.gov/pubmed/12972599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.19.6790-6797.2003
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