Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control

The Wip1 gene is a serine/threonine phosphatase that is induced in a p53-dependent manner by DNA-damaging agents. We show here that Wip1 message is expressed in moderate levels in all organs, but is present at very high levels in the testes, particularly in the postmeiotic round spermatid compartmen...

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Detalhes bibliográficos
Main Authors: Choi, Jene, Nannenga, Bonnie, Demidov, Oleg N., Bulavin, Dmitry V., Cooney, Austin, Brayton, Cory, Zhang, Yongxin, Mbawuike, Innocent N., Bradley, Allan, Appella, Ettore, Donehower, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134641/
https://ncbi.nlm.nih.gov/pubmed/11809801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1094-1105.2002
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